| President | Rev. Peter M. Donohue, OSA, PhD |
| Provost | Patrick G. Maggitti, Ph.D. |
| Executive Vice President | Roger Demareski |
| Vice President for Student Life | Kathleen J. Byrnes, JD |
| Vice President for Mission and Ministry | Rev. Kevin DePrinzio, OSA, PhD |
| Vice President for University Communication & Marketing | Ann E. Diebold |
| Vice President for Human Resources and Affirmative Action Officer | Ray Duffy, MS, SPHR, SHRM-SCP,CBP |
| Vice President for Finance and Chief Financial Officer | Neil J. Horgan |
| Vice President and Director Athletics | Mark W. Jackson |
| Vice President for Facilities Management | Robert H. Morro |
| Vice President for University Advancement | Kevin W. Noller |
| Interim Vice President for Diversity & Inclusion and Chief Diversity Officer | Ariella Robbins |
| Senior Vice Provost for Academics | Craig M. Wheeland, PhD |
| Vice President and General Counsel | E. Michael Zubey, Jr., JD |
| Dean, Charles Widger School of Law | Mark C. Alexander, JD |
| Dean, M. Louise Fitzpatrick College of Nursing | Donna S. Havens, PhD, RN, FAAN |
| Dean, College of Liberal Arts and Sciences | Adele Lindenmeyr, PhD |
| Dean, Villanova School of Business | Wen Mao, PhD |
| Dean, College of Engineering | Michele Marcolongo, PhD |
| Dean, College of Professional Studies | Christine Kelleher Palus, PhD |
| Dean of Students | Tom DeMarco |
| Dean, Enrollment Management | J. Leon Washington |
| Dean of Graduate Studies, Liberal Arts and Sciences |
Emory H. Woodard IV, PhD |